Gut

Modulating the gut-reproductive tract axis: microbial influence on gynaecological cancer pathogenesis and treatment

The gut microbiota plays a crucial role in regulating host immunity, metabolism and inflammation, with accumulating evidence linking its composition and function to the development and progression of ...
gut.bmj

Preclinical stages of Crohn’s disease defined by faecal calprotectin in asymptomatic first-degree relatives

We read with great interest the recent article by Turner et al published in Gut , which evaluated the use of faecal calprotectin to define preclinical stages of Crohn’s disease (CD) in asymptomatic ...
gut.bmj

NSUN6 deficiency drives immune suppression in pancreatic cancer via the KDM5A-CCL2-macrophage axis

Background RNA 5-methylcytosine (m 5 C) has emerged as a critical epigenetic regulator in cancer biology, yet its role in the tumour immune microenvironment (TME) remains incompletely understood.
gut.bmj

A Common CTRB misfolding variant associated with pancreatic cancer risk causes ER stress and inflammation in mice

Background Genome-wide association studies have identified an exon 6 CTRB2 deletion variant proposed to increase pancreatic cancer risk. Conclusions This mouse strain provides evidence that the exon 6 ...
gut.bmj

Microbial determinants of effective donors in faecal microbiota transplantation for UC

Objective Faecal microbiota transplantation (FMT) has variable efficacy in treating UC. Recently, oral lyophilised FMT was found to induce remission in patients with UC, with one donor having 100% ...
gut.bmj

Association between appendectomy and Parkinson’s disease from the UK Biobank

2 Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China ...
gut.bmj

Fructose drives colorectal cancer progression by regulating crosstalk between cancer-associated fibroblasts and tumour cells

2 Tianjin's Clinical Research Center for Cancer, Tianjin, People's Republic of China 3 Tianjin Key Laboratory of Digestive Cancer, Tianjin, People's Republic of China Background Fructose has been ...
gut.bmj

Divergent lineage trajectories and genetic landscapes in human gastric intestinal metaplasia organoids associated with early neoplastic progression

Background Gastric intestinal metaplasia (IM) is a precancerous stage spanning a morphological spectrum that is poorly represented by human cell line models. Objective We aim to establish and ...
gut.bmj

Alterations of gut microbiome in autoimmune hepatitis

Objective The significance of the liver-microbiome axis has been increasingly recognised as a major modulator of autoimmunity. The aim of this study was to take advantage of a large well-defined ...
gut.bmj

Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures

Dr S Blum, Department of Immunology, Nestlé Research Centre, Vers-Chez-les-Blanc, Ch-1000 Lausanne 26, Switzerland. Email: stephanie.blum-sperisen{at}rdls.nestle.com BACKGROUND AND AIM Intestinal ...
gut.bmj

USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation

Correspondence to Professor Xiao Xu, Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China; ...
gut.bmj

Non-invasive risk-based surveillance of hepatocellular carcinoma in patients with metabolic dysfunction-associated steatotic liver disease

15 Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore Background Metabolic dysfunction-associated steatotic liver disease (MASLD) affects over 30% of the general ...