RMD Open

Salvage therapy with JAK inhibitors in refractory Takayasu arteritis: a multicentre experience

Takayasu arteritis (TAK) remains a therapeutic challenge, and some patients develop refractory disease despite conventional ...
RMD Open

Sex and anticitrullinated protein antibodies modify the relationship between inflammation and cardiovascular risk in rheumatoid arthritis

Objectives Female sex and anticitrullinated protein antibodies (ACPA) are associated with higher disease activity in ...
rmdopen.bmj

Real-world effectiveness of b/tsDMARD switching in low-inflammatory difficult-to-treat rheumatoid arthritis: insights from the FIRST registry

Objectives To assess the effectiveness of switching biological or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in patients with low-inflammatory difficult-to-treat rheumatoid ...
rmdopen.bmj

Predicting total knee replacement in knee osteoarthritis using a machine learning-guided approach in patients of the Osteoarthritis Initiative (OAI)

Objective To develop a pragmatic model to predict total knee replacement (TKR) in knee osteoarthritis using non-imaging clinical, genetic and lifestyle data with machine learning (ML)-guided feature ...
rmdopen.bmj

Do high rheumatoid factor levels impact response to certolizumab pegol in patients with inadequately controlled rheumatoid arthritis? A post hoc analysis of the phase IIIb ...

Objectives To assess the impact of rheumatoid factor (RF) levels and previous inadequate responses/intolerance to tumour necrosis factor inhibitors (TNFi-IR) on the efficacy of certolizumab pegol (CZP ...
rmdopen.bmj

Clusters in paediatric Behçet’s disease: a multicentre international study

Objectives Clinical features of Behçet’s disease (BD) exhibit significant variability, not only from patient to patient but also according to gender and geographical region. This study aims to ...
rmdopen.bmj

Predicting the progression of difficult-to-treat rheumatoid arthritis by a machine learning scoring system, from the FIRST registry

Objectives This study aimed to develop and validate a prediction model for the future progression of difficult-to-treat rheumatoid arthritis (D2T RA) and support the precise use of biologic and ...
rmdopen.bmj

Evaluation of serial cardiovascular magnetic resonance monitoring and immunosuppressive therapy in predicting outcomes in systemic sclerosis

Objective Cardiac involvement is a major complication of systemic sclerosis (SSc), with myocardial fibrosis as a hallmark feature. Cardiovascular magnetic resonance (CMR) is used to detect cardiac ...
rmdopen.bmj

Correction: Spotlight on Sjögren’s: a patient perspective on burden of illness and unmet needs – results from a real-world survey

Marvel J, Kenney G, Church J, et al. Spotlight on Sjögren’s: a patient perspective on burden of illness and unmet needs – results from a real-world survey. RMD Open 2026;12:e006166. This article has ...
rmdopen.bmj

Comparative effectiveness and persistence of ixekizumab and other b/tsDMARDs in patients with PsA from a real-world setting: 12-month results from the PRO-SPIRIT study

Objectives This prespecified interim analysis of the PRO-SPIRIT observational study compares the effectiveness and persistence of ixekizumab (IXE) with other biologic or targeted synthetic ...
rmdopen.bmj

Impact of ANCA specificity on risk of cardiovascular events and death in ANCA-associated vasculitis

Objective The aim of this study was to investigate the relationship between antineutrophil cytoplasmic antibodies (ANCA) specificity and the risk of major adverse cardiovascular events (MACE) in ...
rmdopen.bmj

Determinants of radiographic progression in early psoriatic arthritis: insights from a real-world cohort

Objective Persistent articular inflammation in psoriatic arthritis (PsA) is associated with radiographic damage. Despite advances in diagnosis and therapy, radiographic structural damage remains ...